Leaders | Players | Teams | Award Races
| Pos | Player | Team | GP | G | A | Pts | +/- | PIM | PP | SH | GW | GT | Hits | Shots | % |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | Andrew Cogliano | | 82 | 24 | 46 | 70 | 8 | 28 | 3 | 2 | 7 | 0 | 76 | 180 | 13.3 |
| C | * Victor Borbov | | 80 | 24 | 41 | 65 | 3 | 44 | 2 | 0 | 7 | 1 | 76 | 184 | 13.0 |
| LW | * Vojtech Polak | | 79 | 22 | 42 | 64 | 1 | 44 | 4 | 0 | 3 | 0 | 59 | 162 | 13.6 |
| LW | Ryane Clowe | | 82 | 27 | 35 | 62 | -2 | 57 | 7 | 0 | 5 | 1 | 165 | 200 | 13.5 |
| C | * Michael Rupp | | 75 | 27 | 31 | 58 | 1 | 86 | 9 | 1 | 5 | 2 | 50 | 187 | 14.4 |
| RW | * Chad LaRose | | 80 | 19 | 34 | 53 | 13 | 44 | 1 | 0 | 4 | 0 | 51 | 160 | 11.9 |
| LW | * David Booth | | 76 | 25 | 27 | 52 | -3 | 57 | 1 | 1 | 2 | 0 | 57 | 181 | 13.8 |
| D | Victor Hedman | | 82 | 15 | 32 | 47 | 13 | 48 | 6 | 0 | 2 | 0 | 187 | 189 | 7.9 |
| D | * Alexei Semenov | | 78 | 11 | 33 | 44 | -2 | 52 | 2 | 0 | 0 | 0 | 274 | 163 | 6.7 |
| D | Keaton Ellerby | | 79 | 7 | 27 | 34 | 2 | 65 | 2 | 1 | 2 | 0 | 219 | 144 | 4.9 |
| D | Aaron Ness | | 82 | 6 | 19 | 25 | 1 | 116 | 1 | 0 | 1 | 0 | 125 | 125 | 4.8 |
| LW | * Cal O'Reilly | | 70 | 3 | 10 | 13 | -3 | 26 | 0 | 0 | 0 | 0 | 20 | 44 | 6.8 |
| LW | * Ryan Hillier | | 39 | 4 | 8 | 12 | 1 | 10 | 0 | 0 | 1 | 0 | 12 | 28 | 14.3 |
| D | * John-Michael Liles | | 82 | 4 | 7 | 11 | -11 | 20 | 0 | 0 | 0 | 0 | 41 | 71 | 5.6 |
| C | Mike Santorelli | | 23 | 4 | 7 | 11 | -3 | 17 | 3 | 0 | 0 | 0 | 15 | 31 | 12.9 |
| C | * Pavel Vorobiev | | 19 | 5 | 4 | 9 | 2 | 12 | 0 | 2 | 0 | 0 | 13 | 26 | 19.2 |
| C | Kevin Lynch | | 10 | 2 | 3 | 5 | 2 | 4 | 0 | 0 | 0 | 0 | 7 | 10 | 20.0 |
| LW | * Mark Tobin | | 66 | 2 | 3 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 10 | 11 | 18.2 |
| RW | * Ryan Callahan | | 19 | 4 | 1 | 5 | -4 | 39 | 0 | 0 | 0 | 0 | 7 | 22 | 18.2 |
| D | Andrew Campbell | | 43 | 0 | 3 | 3 | 9 | 2 | 0 | 0 | 0 | 0 | 15 | 11 | 0.0 |
| RW | * Colin Hemingway | | 60 | 1 | 2 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 13 | 11 | 9.1 |
| C | Louie Caporusso | | 10 | 0 | 3 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 1 | 9 | 0.0 |
| D | Mark Pysyk | | 13 | 0 | 3 | 3 | -8 | 0 | 0 | 0 | 0 | 0 | 18 | 16 | 0.0 |
| LW | Markus Granlund | | 24 | 1 | 2 | 3 | -4 | 12 | 0 | 0 | 0 | 0 | 6 | 19 | 5.3 |
| D | * Michael Sauer | | 19 | 1 | 2 | 3 | 0 | 8 | 0 | 0 | 0 | 0 | 20 | 30 | 3.3 |
